The herbarium contains approximately 11,000 herbarium sheets and vascular plants. These include approximately 2600 specimens from the Botanical Society, which had Saxony-Anhalt and Central Germany as its main collecting focus. In addition, there are numerous specimens from other regions of Central Europe. Important specimens from the period before 1945 were collected by Max Otto Dietrich, Wilhelm M.E.L. Giese and Ernst Manzek, among others. The Magdeburg urban area is covered by a current collection from the 1990s by Siegfried Nickolmann. The herbarium of the Wolfsburg collector Hans-Dietrich Laatsch spans a greater range of regions: comprising close to 6,000 sheets, it contains seed plants from all five continents, carefully identified according to excursion floras and with the help of manuals. Important plant species from the various floral kingdoms, including those from the South African Cape Province, are represented in this part of the herbarium.
A second part of the collection is dedicated to lower plants: mosses and lichens, as well as mushrooms, add a total of 1,400 specimens, the majority of which were collected by Prof. Wulf Pohle. The collection focus of this section is also Saxony-Anhalt.